AMICUS

AI in Medical Imaging for novel Cancer User Support

Medical imaging impacts key decisions in cancer care which may be supported by deep-learning based artificial intelligence. But this requires large volumes of privacy-sensitive imaging data which are dispersed across hospitals. In AMICUS we develop and apply technology for privacy-preserving distributed deep learning from existing hospital imaging archives.

This is a grant from the Dutch Research Council (NWO); Applied and Engineering Sciences, dossiernr. 17924.

The Project Lead

The Team

Partners

  • Stichting Koningin Wilhelmina Fonds voor de Nederlandse Kankerbestrijding (KWF kankerbestrijding), Amsterdam, the Netherlands
  • Maastricht University, Maastricht, the Netherlands
  • Universtiy of Twente, Enschede, the Netherlands
  • University Medical Center Groningen, Groningen, the Netherlands
  • Tilburg University, Tilburg, the Netherlands
  • Varian Medical Systems, California, USA
  • Medical Data Works, Heerlen, the Netherlands

Publications

A Comparative Study of Federated Learning Models for COVID-19 Detection

Deep learning is effective in diagnosing COVID-19 and requires a large amount of data to be effectively trained. Due to data and privacy regulations, hospitals generally have no access to data from other hospitals. Federated learning (FL) has been used to solve this problem, where it utilizes a distributed setting to train models in hospitals in a privacy-preserving manner. Deploying FL is not always feasible as it requires high computation and network communication resources. This paper evaluates five FL algorithms’ performance and resource efficiency for Covid-19 detection. A decentralized setting with CNN networks is set up, and the performance of FL algorithms is compared with a centralized environment. We examined the algorithms with
varying numbers of participants, federated rounds, and selection algorithms.
Our results show that cyclic weight transfer can have better overall performance, and results are better with fewer participating hospitals. Our results demonstrate good performance for detecting COVID-19 patients and might be useful in deploying FL algorithms for covid-19 detection and medical image analysis in general.

Federated Learning in Medical Imaging: Part I: Toward Multicentral Health Care Ecosystems

With recent developments in medical imaging facilities, extensive medical imaging data are produced every day. This increasing amount of data provides an opportunity for researchers to develop data-driven methods and deliver better health care. However, data-driven models require a large amount of data to be adequately trained. Furthermore, there is always a limited amount of data available in each data center. Hence, deep learning models trained on local data centers might not reach their total performance capacity. One solution could be to accumulate all data from different centers into one center. However, data privacy regulations do not allow medical institutions to easily combine their data, and this becomes increasingly difficult when institutions from multiple countries are involved. Another solution is to use privacy-preserving algorithms, which can make use of all the data available in multiple centers while keeping the sensitive data private. Federated learning (FL) is such a mechanism that enables deploying large-scale machine learning models trained on different data centers without sharing sensitive data. In FL, instead of transferring data, a general model is trained on local data sets and transferred between data centers. FL has been identified as a promising field of research, with extensive possible uses in medical research and practice. This article introduces FL, with a comprehensive look into its concepts and recent research trends in medical imaging.

Federated Learning in Medical Imaging: Part II: Methods, Challenges, and Considerations

Federated learning is a machine learning method that allows decentralized training of deep neural networks among multiple clients while preserving the privacy of each client's data. Federated learning is instrumental in medical imaging because of the privacy considerations of medical data. Setting up federated networks in hospitals comes with unique challenges, primarily because medical imaging data and federated learning algorithms each have their own set of distinct characteristics. This article introduces federated learning algorithms in medical imaging and discusses technical challenges and considerations of real-world implementation of them.

Data Storage, Cloud Usage and Artificial Intelligence Pipeline

Artificial intelligence (AI), and especially deep learning, requires vast amounts of data for training, testing and validation. Collecting these data and the corresponding annotations requires the implementation of imaging biobanks that provide access to these data in a standardized way. This in turn requires careful design and implementation based on the current standards and guidelines and complying to the current legal restrictions. However, just the realization of proper imaging data collections is not sufficient to train, validate and deploy AI as resource demands are high and requires a careful hybrid implementation of AI pipelines both on premise and in the cloud.

This chapter aims to help the reader when technical considerations have to be made about the AI environment by providing a technical background of different concepts and implementation aspects that are involved in data storage, cloud usage and AI pipelines.

Systematic Review of Health Economic Evaluations Focused on Artificial Intelligence in Healthcare: The Tortoise and the Cheetah

This study aimed to systematically review recent health economic evaluations (HEEs) of artificial intelligence (AI) applications in healthcare. The aim was to discuss pertinent methods, reporting quality and challenges for future implementation of AI in healthcare, and additionally advise future HEEs.

Current applications of deep-learning in neuro-oncological MRI

Magnetic Resonance Imaging (MRI) provides an essential contribution in the screening, detection, diagnosis, staging, treatment and follow-up in patients with a neurological neoplasm. Deep learning (DL), a subdomain of artificial intelligence has the potential to enhance the characterization, processing and interpretation of MRI images. The aim of this review paper is to give an overview of the current state-of-art usage of DL in MRI for neuro-oncology.